Synthesis and NMR elucidation of novel tetrapeptides (pages 114–121)
Maya Makatini, Thashini Chetty, Oluseye K. Onajole, Thavendran Govender, Patrick Govender, Glenn E. M. Maguire and Hendrik G. Kruger
Article first published online: 11 NOV 2011 | DOI: 10.1002/psc.1423
The synthesis and NMR elucidation of Ala-Val-Pro-Ile and five novel peptide-based derivatives that mimic the natural second mitochondria-derived activator of caspase (Smac) protein are reported. The use of 2D NMR techniques with the inclusion of efficient adiabatic symmetrized ROESY proves to be effective tools to elucidate the structures.