Dimeric analogs of immunosuppressive decapeptide fragment of ubiquitin (pages 456–465)
Alicja Kluczyk, Marzena Cydzik, Monika Biernat, Remigiusz Bąchor, Paweł Pasikowski, Piotr Stefanowicz, Jolanta Artym, Michał Zimecki and Zbigniew Szewczuk
Article first published online: 25 MAY 2012 | DOI: 10.1002/psc.2416
Three dimerization strategies via PEG derivatives were used to synthesize the analogs of LEDGRTLSDY ubiquitin fragment on solid support. The immunological tests showed that the head-to-tail dimerization causes a more profound increase in the biological activity than other tested dimerization methods.