Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities (pages 500–510)
Sloan Ayers, Brandie M. Ehrmann, Audrey F. Adcock, David J. Kroll, Esperanza J. Carcache de Blanco, Qi Shen, Steven M. Swanson, Joseph O. Falkinham III, Mansukh C. Wani, Sheila M. Mitchell, Cedric J. Pearce and Nicholas H. Oberlies
Version of Record online: 29 JUN 2012 | DOI: 10.1002/psc.2425
Fifteen peptaibols were isolated and characterized from two different fungal cultures; eight are new to the literature. The compounds were sequenced by MS/MS using higher-energy collisional dissociation and high field NMR (950 MHz), both of which facilitated structure elucidation, and the absolute configuration of the amino acid residues was determined using Marfey's analysis via the development of a 10-min ultra performance liquid chromatography method. The compounds were examined against a suite of biological assays, including cytotoxicity, antibacterial activity, and anthelmintic activity.