Peptide inhibitors against herpes simplex virus infections (pages 148–158)
Stefania Galdiero, Annarita Falanga, Rossella Tarallo, Luigi Russo, Emilia Galdiero, Marco Cantisani, Giancarlo Morelli and Massimiliano Galdiero
Version of Record online: 7 FEB 2013 | DOI: 10.1002/psc.2489
Herpes simplex virus (HSV) is a significant human pathogen, and the development of novel strategies to eradicate HSV is a global public health priority. A therapeutic strategy at the moment not fully addressed is the use of small peptide molecules, either modeled on viral proteins or derived from antimicrobial peptides, designed to interrupt protein–protein or viral protein–host cell membrane interactions. This review summarizes current knowledge and strategies in the development of peptides to inhibit HSV infectivity. Here is reported the three-dimensional structure of an inhibitory peptide derived from glycoprotein H of herpes simplex type I.