Journal of Peptide Science

Cover image for Vol. 19 Issue 3

March 2013

Volume 19, Issue 3

Pages 127–180

  1. Reviews

    1. Top of page
    2. Reviews
    3. THIS ARTICLE HAS BEEN RETRACTED
    4. Research Articles
    1. You have full text access to this OnlineOpen article
      Max Bergmann lecture protein epitope mimetics in the age of structural vaccinology (pages 127–140)

      John A. Robinson

      Version of Record online: 24 JAN 2013 | DOI: 10.1002/psc.2482

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      The growing structural database of biological macromolecules can be exploited for the design of smaller synthetic ‘protein epitope mimetics’. The mimetics should reproduce the folded structures of protein epitopes and then provide a rich source of lead molecules for applications in drug and vaccine research. This field is reviewed here, with a focus on the design of β-hairpin epitope mimetics and their applications in antibiotic discovery and synthetic vaccine design.

    2. Fmoc-based peptide thioester synthesis with self-purifying effect: heading to native chemical ligation in parallel formats (pages 141–147)

      Franziska Thomas

      Version of Record online: 7 FEB 2013 | DOI: 10.1002/psc.2494

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      An Fmoc-based peptide thioester synthesis with self-purifying effect is described. A cyclization–thiolysis reaction sequence on the sulfonamide ‘safety-catch’ linker allows the selective detachment of the truncation products and the full-length peptide thioester. The method paves the way for the parallel synthesis of peptide thioesters and consequently expands the applicability of the native chemical ligation to the synthesis of parallel formats such as protein arrays.

    3. Peptide inhibitors against herpes simplex virus infections (pages 148–158)

      Stefania Galdiero, Annarita Falanga, Rossella Tarallo, Luigi Russo, Emilia Galdiero, Marco Cantisani, Giancarlo Morelli and Massimiliano Galdiero

      Version of Record online: 7 FEB 2013 | DOI: 10.1002/psc.2489

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      Herpes simplex virus (HSV) is a significant human pathogen, and the development of novel strategies to eradicate HSV is a global public health priority. A therapeutic strategy at the moment not fully addressed is the use of small peptide molecules, either modeled on viral proteins or derived from antimicrobial peptides, designed to interrupt protein–protein or viral protein–host cell membrane interactions. This review summarizes current knowledge and strategies in the development of peptides to inhibit HSV infectivity. Here is reported the three-dimensional structure of an inhibitory peptide derived from glycoprotein H of herpes simplex type I.

  2. THIS ARTICLE HAS BEEN RETRACTED

    1. Top of page
    2. Reviews
    3. THIS ARTICLE HAS BEEN RETRACTED
    4. Research Articles
    1. Retracted: S14G-humanin inhibits Aβ1–42 fibril formation, disaggregates preformed fibrils, and protects against Aβ-induced cytotoxicity in vitro (pages 159–165)

      Wei Zhang, Ying Du, Miao Bai, Ye Xi, Zhuyi Li and Jianting Miao

      Version of Record online: 24 JAN 2013 | DOI: 10.1002/psc.2484

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      The effect of S14G-humanin (HNG) on inhibiting monomeric Aβ1–42 aggregation and destabilizing preformed Aβ1–42 fibrils has been studied. Thioflavin T fluorescence assay revealed that HNG could significantly inhibit monomeric Aβ1–42 aggregation into fibrils (A) and destabilize preformed Aβ1–42 fibrils (B) in a concentration-dependent manner. This study provides the novel evidence that HNG may have anti-Aβ fibrillogenesis and fibril-destabilizing properties, suggesting that HNG may have promising therapeutic potential as a multitarget agent for the prevention and treatment of Alzheimer's disease.

  3. Research Articles

    1. Top of page
    2. Reviews
    3. THIS ARTICLE HAS BEEN RETRACTED
    4. Research Articles
    1. Characterization of the effects of opiorphin and sialorphin and their analogs substituted in position 1 with pyroglutamic acid on motility in the mouse ileum (pages 166–172)

      Elżbieta Kamysz, Maciej Sałaga, Marta Sobczak, Wojciech Kamysz and Jakub Fichna

      Version of Record online: 4 FEB 2013 | DOI: 10.1002/psc.2486

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      In the present study, we characterized the effect of opiorphin and sialorphin on the mouse ileum motility in vitro and in vivo. We also examined whether glutamine residue in position 1 is crucial for the pharmacological action of these peptides.

    2. Effective antimicrobial activity of Cbf-K16 and Cbf-A7A13 against NDM-1-carrying Escherichia coli by DNA binding after penetrating the cytoplasmic membrane in vitro (pages 173–180)

      Qingru Hao, Hui Wang, Jing Wang, Jie Dou, Min Zhang, Weidong Zhou and Changlin Zhou

      Version of Record online: 7 FEB 2013 | DOI: 10.1002/psc.2488

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      Cbf-K16 and Cbf-A7A13 effectively killed New Delhi metallo-beta-lactamase-1-carrying bacteria in vitro. The peptides bound to DNA after penetrating the cytoplasmic membrane. Cationic charges of the peptides played a key role in their antimicrobial activity.

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