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Journal of Peptide Science

Cover image for Vol. 20 Issue 1

January 2014

Volume 20, Issue 1

Pages i–iii, 1–61

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Research Articles
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      Issue information (pages i–iii)

      Article first published online: 19 DEC 2013 | DOI: 10.1002/psc.2556

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  2. Research Articles

    1. Top of page
    2. Issue Information
    3. Research Articles
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      BOP-OXy, BOP-OBt, and BOP-OAt: novel organophosphinic coupling reagents useful for solution and solid-phase peptide synthesis (pages 1–6)

      Ayman El-Faham, Sherine N. Khattab, Ramon Subirós-Funosas and Fernando Albericio

      Article first published online: 22 NOV 2013 | DOI: 10.1002/psc.2579

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      BOP-OXy, BOP-OBt, and BOP-OAt coupling reagents show efficient performance in solution and SPPS. BOP-OXy shows the additional advantage of being highly soluble in DMF and even fairly soluble in CH3CN.

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      Development of a neuromedin U–human serum albumin conjugate as a long-acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide (pages 7–19)

      Philippe Neuner, Andrea M. Peier, Fabio Talamo, Paolo Ingallinella, Armin Lahm, Gaetano Barbato, Annalise Di Marco, Kunal Desai, Karolina Zytko, Ying Qian, Xiaobing Du, Davide Ricci, Edith Monteagudo, Ralph Laufer, Alessandro Pocai, Elisabetta Bianchi, Donald J. Marsh and Antonello Pessi

      Article first published online: 13 NOV 2013 | DOI: 10.1002/psc.2582

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      Conjugation of the endogenous peptide neuromedin U to albumin yields a compound with long-lasting body-weight lowering and glucose-tolerance improving effects.

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      Synthesis and antimicrobial activity of α-aminoboronic-containing peptidomimetics (pages 20–24)

      Olga V. Gozhina, John Sigurd Svendsen and Tore Lejon

      Article first published online: 13 NOV 2013 | DOI: 10.1002/psc.2583

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      Synthesis and in vitro testing of 175 α-amino boronic acid/boronate-containing dipeptides and tripeptides.

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      Mining antimicrobial peptides from small open reading frames in Ciona intestinalis (pages 25–29)

      Yongzhong Lu, Yu Zhuang and Jie Liu

      Article first published online: 19 NOV 2013 | DOI: 10.1002/psc.2584

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      Over 180 peptides deduced from the small open reading frames distributed in Chromosome 2 of Ciona intestinalis were predicted by bioinformatics approaches to be antimicrobial peptides, and some of which were proved to be active.

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      Evaluation of acid-labile S-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis (pages 30–35)

      Hajime Hibino, Yasuyoshi Miki and Yuji Nishiuchi

      Article first published online: 28 NOV 2013 | DOI: 10.1002/psc.2585

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      The 4,4'-dimethoxydiphenylmethyl and 4-methoxybenzyloxymethyl groups were shown to be acid-labile S-protecting groups that can suppress racemization of Cys to an acceptable level (< 1.0%) even when its Fmoc derivatives are incorporated via the standard SPPS protocol of phosphonium or uronium reagents with the aid of DIEA in DMF.

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      Mimicking hemoproteins: a new synthetic metalloenzyme based on a Fe(III)-mesoporphyrin functionalized by two helical decapeptides (pages 36–45)

      Mariano Venanzi, Sabrina Cianfanelli and Antonio Palleschi

      Article first published online: 19 NOV 2013 | DOI: 10.1002/psc.2586

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      A new metalloenzyme, comprising a Fe(III)-mesoporphyrin IX group functionalized by two decapeptide chains, mimics function and structural features of a hemoprotein active site, hosting the reactants in a restrained environment where catalysis occurs.

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      A novel modified peptide derived from membrane-proximal external region of human immunodeficiency virus type 1 envelope significantly enhances retrovirus infection (pages 46–54)

      Lishuang Zhang, Chunlai Jiang, Huayan Zhang, Xin Gong, Lan Yang, Liang Miao, Yuhua Shi, Yan Zhang, Wei Kong, Chuntao Zhang and Yaming Shan

      Article first published online: 19 NOV 2013 | DOI: 10.1002/psc.2587

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      A novel MPER-derived peptide, P16, was designed to significantly enhance retrovirus infection.

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      A novel post-ligation thioesterification device enables peptide ligation in the N to C direction: synthetic study of human glycodelin (pages 55–61)

      Takaomi Takenouchi, Hidekazu Katayama, Yuko Nakahara, Yoshiaki Nakahara and Hironobu Hojo

      Article first published online: 12 DEC 2013 | DOI: 10.1002/psc.2592

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      N-Ethyl-S-acetamidomethylcysteine could be used as a post-ligation thioesterification device. Using it, we successfully synthesized human glycodelin polypeptide consisting of 162 amino acid residues and two N-linked glycans by the fully convergent method.

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