Screening and identification of a specific peptide binding to hepatocellular carcinoma cells from a phage display peptide library (pages 196–202)
Yonge Guo, Caixia Ma, Chunyan Li, Jinling Wu, Dan Zhang, Juanjuan Han, Qixuan Wang, Jinhui Xu, Shaoying Lu and Yingchun Hou
Version of Record online: 30 JAN 2014 | DOI: 10.1002/psc.2599
The specific binding to HepG2 cells indicates that HCSP4-fluorescein isothiocyanate (FITC) may be a promising lead candidate for molecular imaging and targeted drug delivery in the diagnosis and therapy of hepatocellular carcinoma. A, B: HCSP4-FITC binds to HepG2 cells specifically; C, D: the nuclei (C) and membrane (D) of HepG2 cells are displayed using DAPI and Dil staining methods; E, F: the merged photos show that HCSP4-FITC binds to the surfaces of HepG2 cells specifically.