Incorporation and characterization of boron neutron capture therapy agents into mesoporous silicon and silicon nanowires



The tunable pore size, biodegradability, and surface chemistry of mesoporous silicon (BioSiliconTM) are important to a broad spectrum of uses for drug delivery. For the case of Boron Neutron Capture Therapy (BNCT), encapsulation of a given boron-containing drug molecule within a porous BioSiliconTM microparticle provides a vehicle for a brachytherapy method that avoids the necessity of drug modification. In this work, the loading and characterization of three clinically approved BNCT drugs into mesoporous Si is demonstrated. Because of difficulties associated with light element detection, a method based on a Beer's Law analysis of selected FTIR vibrational bands has been developed to estimate boron-containing drug loading in these materials. As a complementary nanostructural platform, a cathodic deposition process for the surface enriched growth of selected drugs onto the surface of silicon nanowires is also described. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)