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Keywords:

  • 61.43.Gt;
  • 66.30.Pa;
  • 81.05.Rm;
  • 82.35.Np

Abstract

In this study, biodegradable mesoporous Si (BioSiliconTM) was loaded with cis-(2,2′-bipyridine) dichlororuthenium (II) (Ru complex) as a model hydrophobic compound. This ruthenium complex-loaded BioSiliconTM was either partially embedded on the surface of electrospun polycaprolactone (PCL) fibers or fully encapsulated within the fibers. To study release profiles in the above model delivery systems, porous Si/PCL constructs were soaked in DI water at 37 °C and the UV–Vis absorption spectrum of the supernatant was measured as a function of time. These results show that the Ru complex was released in a sustained manner over 7-day period. In addition, it is shown that the controlled-release of this complex depends on both the spatial location of the complex in the PCL fibrous scaffolds as well as the amount of Ru compound loaded in the mesoporous Si. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)