Thumbnail image of graphical abstract

In recent years, nanocavity redox cycling has evolved into an interesting technique for a wide range of sensing applications. The sensor design is based on two closely-spaced and individually-biased electrodes that are incorporated into a nanofluidic channel. This setup enables the repeated participation of certain molecules in subsequent redox reactions at the two electrodes, hence leading to a strong amplification of the electrochemical signal. Kätelhön and Wolfrum (pp. 881–884) describe a simulation framework for the modeling of electrochemical processes within such nanocavity redox-cycling devices.

The image shows an illustration of a random-walk approach for the simulation of the redox-cycling effect. A single molecule trajectory is indicated; differently coloured spheres specify the molecule occupying different oxidation states throughout the molecules pathway.