Dewetting of poly(lactic-co-glycolic acid) films is a new versatile method for designing breath figure structures on nanoscale rate. Most of the techniques known for the construction of nanostructured surfaces can only be applied for coating very small areas; however, the method presented by Eyas Dayyoub et al. (pp. 1279–1283) has high potential for patterning films without limitation of the surface size. Variations of dewetting parameters lead to different pore sizes and surface roughness. Adhesion of bacteria (i.e., Escherichia coli) on various surfaces was investigated to determine the influence of such structures on bacteria behaviour. The surface with the largest pore size (about 500 nm on average) showed the highest anti-adhesive properties. Decreasing the pore sizes to below 500 nm reduced the anti-adhesive properties of the films. Unstructured PLGA films, prepared by the spin-coating method, exhibited the lowest anti-adhesive properties. These findings show how the bacterial adhesion can be controlled by film structuring. On the Front Cover, a nanostructured poly(lactic-coglycolic acid) film prepared by the dewetting method is displayed.