The conduction electrons can deliver an indirect exchange interaction, namely the RKKY interaction, between impurities dissolved in nonmagnetic metal hosts by the interaction between the conduction electron spins and localized impurity spins. The effect of the laser field on the RKKY interaction between two localized spins in two-dimensional metals is studied by a quantum theory in this paper. The calculation results indicate an intense laser field can effectively manipulate this kind of indirect exchange interaction. The threshold of field strength for achieving this effect is given, and the exchange integrals at different impurity separations and laser field strengths are exhibited. It is discussed that both the finite spatial extension of the interaction potential and thermal energy of irradiation with a laser can influence the RKKY interaction.