Contributed Article

Spiking rate of myenteric neurons recorded from multi-electrode arrays depending on local microenvironment

  1. Rebekka Medert,
  2. Anne Schuster,
  3. Lukas Kristoffer Schwarz,
  4. Tanja Schwab,
  5. Karl-Herbert Schaefer†,*

Article first published online: 22 FEB 2013

DOI: 10.1002/pssc.201200808

Issue

physica status solidi (c)

physica status solidi (c)

Special Issue: 39th International Symposium on Compound Semiconductors (ISCS 2012) see one further paper in Phys. Status Solidi B 250, No. 4 (2013).

Volume 10, Issue 5, pages 877–881, May 2013

Additional Information

How to Cite

Medert, R., Schuster, A., Schwarz, L. K., Schwab, T. and Schaefer, K.-H. (2013), Spiking rate of myenteric neurons recorded from multi-electrode arrays depending on local microenvironment. Phys. Status Solidi C, 10: 877–881. doi: 10.1002/pssc.201200808

Author Information

  1. Enteric Nervous System Group, University of Applied Sciences Kaiserslautern, Amerikastraße 1, 66482 Zweibrücken, Germany

  1. †

    Present address: Department of Biotechnology, University of Applied Sciences, Amerikastraße 1, 66482 Zweibrücken, Germany

*Phone: +49 63137245418, Fax: +49 63137245305

  1. †

    Present address: Department of Biotechnology, University of Applied Sciences, Amerikastraße 1, 66482 Zweibrücken, Germany

Publication History

  1. Issue published online: 21 MAY 2013
  2. Article first published online: 22 FEB 2013
  3. Manuscript Revised: 31 DEC 2013
  4. Manuscript Accepted: 7 JAN 2013
  5. Manuscript Received: 8 OCT 2012

Funded by

  • University of Applied Sciences Kaiserslautern

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Keywords:

  • microenvironment;
  • myenteric neurons;
  • multi-electrode arrays;
  • calcium channel

Abstract

The interaction of cells with their microenvironment is an important factor, which influences phenotype, differentiation state and cell function. Interactions between cells and extracellular matrix (ECM) components are of crucial significance, especially for the development of electrical activity in neurons. For this study multi-electrode arrays were used to examine the influence of different substrates (glass, poly-D-lysine (PDL), PDL/laminin and laminin) on myenteric neurons during stimulation with lipopolysaccharide (LPS). The effect of LPS upon neurons grown on PDL/laminin resulted in an increased neuronal activity and calcium influx through L-type voltage gated calcium channels. Cultures on glass or PDL were not influenced. This demonstrates that the local microenvironment plays an essential role for the electrical potential of myenteric neurons.(© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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