Multivariate extreme value modelling of laboratory safety data from clinical studies
Article first published online: 8 AUG 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 11, Issue 5, pages 367–372, September/October 2012
How to Cite
Southworth, H. and Heffernan, J. E. (2012), Multivariate extreme value modelling of laboratory safety data from clinical studies. Pharmaceut. Statist., 11: 367–372. doi: 10.1002/pst.1531
- Issue published online: 17 SEP 2012
- Article first published online: 8 AUG 2012
- extreme values;
- clinical trials;
Generally, in the interpretation of clinical safety laboratory data, it is extreme values that indicate potential safety issues. We illustrate the application of multivariate extreme value modelling to such data. Applying the methods to a clinical trial dataset, we find unexpected extremal relationships that have potentially important implications for the interpretation of such data. Copyright © 2012 John Wiley & Sons, Ltd.