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Main Paper
Bayesian fitting of a logistic dose–response curve with numerically derived priors
Article first published online: 25 SEP 2008
DOI: 10.1002/pst.348
Copyright © 2008 John Wiley & Sons, Ltd.
1539-1612/asset/cover.gif?v=1&s=8d27b9f38af39e9c87d028148e085afe88ed14bf "Pharmaceutical Statistics")
Additional Information
How to Cite
Huson, L. W. and Kinnersley, N. (2009), Bayesian fitting of a logistic dose–response curve with numerically derived priors. Pharmaceutical Statistics, 8: 279–286. doi: 10.1002/pst.348
Publication History
- Issue published online: 14 DEC 2009
- Article first published online: 25 SEP 2008
- Abstract
- References
- Cited By
Keywords:
- Bayesian;
- simulation;
- bootstrap
Abstract
In this report we describe the Bayesian analysis of a logistic dose–response curve in a Phase I study, and we present two simple and intuitive numerical approaches to construction of prior probability distributions for the model parameters. We combine these priors with the expert prior opinion and compare the results of the analyses with those obtained from the use of alternative prior formulations. Copyright © 2008 John Wiley & Sons, Ltd.