Bayesian fitting of a logistic dose–response curve with numerically derived priors
Version of Record online: 25 SEP 2008
Copyright © 2008 John Wiley & Sons, Ltd.
Volume 8, Issue 4, pages 279–286, October/December 2009
How to Cite
Huson, L. W. and Kinnersley, N. (2009), Bayesian fitting of a logistic dose–response curve with numerically derived priors. Pharmaceut. Statist., 8: 279–286. doi: 10.1002/pst.348
- Issue online: 14 DEC 2009
- Version of Record online: 25 SEP 2008
In this report we describe the Bayesian analysis of a logistic dose–response curve in a Phase I study, and we present two simple and intuitive numerical approaches to construction of prior probability distributions for the model parameters. We combine these priors with the expert prior opinion and compare the results of the analyses with those obtained from the use of alternative prior formulations. Copyright © 2008 John Wiley & Sons, Ltd.