Estimating time to steady state using the effective rate of drug accumulation
Article first published online: 24 DEC 2009
Copyright © 2009 John Wiley & Sons, Ltd.
Volume 10, Issue 1, pages 27–33, January/February 2011
How to Cite
Panebianco, D. L. and Maes, A. (2011), Estimating time to steady state using the effective rate of drug accumulation. Pharmaceut. Statist., 10: 27–33. doi: 10.1002/pst.404
- Issue published online: 24 DEC 2009
- Article first published online: 24 DEC 2009
- Manuscript Accepted: 7 SEP 2009
- Manuscript Revised: 1 JUN 2009
- Manuscript Received: 2 APR 2008
- steady state;
- elimination rate
Unless all of a drug is eliminated during each dosing interval, the plasma concentrations within a dosing interval will increase until the time course of change in plasma concentrations becomes invariant from one dosing interval to the next, resulting in steady state. A simple method for estimating drug concentration time to steady state based on multiple dose area under the plasma concentration–time curve and effective rate of drug accumulation is presented. Several point estimates and confidence intervals for time to 90% of steady state are compared, and a recommendation is made on how to summarize and present the results. Copyright © 2009 John Wiley & Sons, Ltd.