Fitting Emax models to clinical trial dose–response data
Version of Record online: 28 APR 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Volume 10, Issue 2, pages 143–149, March/April 2011
How to Cite
Kirby, S., Brain, P. and Jones, B. (2011), Fitting Emax models to clinical trial dose–response data. Pharmaceut. Statist., 10: 143–149. doi: 10.1002/pst.432
- Issue online: 29 MAR 2011
- Version of Record online: 28 APR 2010
- clinical trial;
- Emax model;
- model selection;
- non-linear model
We consider fitting Emax models to the primary endpoint for a parallel group dose–response clinical trial. Such models can be difficult to fit using Maximum Likelihood if the data give little information about the maximum possible response. Consequently, we consider alternative models that can be derived as limiting cases, which can usually be fitted. Furthermore we propose two model selection procedures for choosing between the different models. These model selection procedures are compared with two model selection procedures which have previously been used. In a simulation study we find that the model selection procedure that performs best depends on the underlying true situation. One of the new model selection procedures gives what may be regarded as the most robust of the procedures. Copyright © 2010 John Wiley & Sons, Ltd.