Testing non-inferiority and superiority for two endpoints for several treatments with a control
Article first published online: 14 OCT 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Volume 10, Issue 4, pages 318–324, July/August 2011
How to Cite
Lawrence, J. (2011), Testing non-inferiority and superiority for two endpoints for several treatments with a control. Pharmaceut. Statist., 10: 318–324. doi: 10.1002/pst.468
- Issue published online: 25 JUL 2011
- Article first published online: 14 OCT 2010
- multiple comparisons with a control;
- Dunnett's test;
- Gatekeeping tests
Some multiple comparison procedures are described for multiple armed studies. The procedures are appropriate for testing all hypotheses for comparing two endpoints and multiple test arms to a single control group, for example three different fixed doses compared to a placebo. The procedure assumes that among the two endpoints, one is designated as a primary endpoint such that for a given treatment arm, no hypothesis for the secondary endpoint can be rejected unless the hypothesis for the primary endpoint was rejected. The procedures described control the family-wise error rate in the strong sense at a specified level α. Copyright © 2010 John Wiley & Sons, Ltd.