Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro
Version of Record online: 1 MAY 2003
Copyright © 2003 John Wiley & Sons, Ltd.
Volume 17, Issue 5, pages 449–453, May 2003
How to Cite
Huang, R.-L., Huang, Y.-L., Ou, J.-C., Chen, C.-C., Hsu, F.-L. and Chang, C. (2003), Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro. Phytother. Res., 17: 449–453. doi: 10.1002/ptr.1167
- Issue online: 1 MAY 2003
- Version of Record online: 1 MAY 2003
- Manuscript Accepted: 27 NOV 2001
- Manuscript Received: 26 JUL 2001
- National Science Council, Taipei, Taiwan, Republic of China. Grant Numbers: NSC87-2314-B-077-012, NSC87-2314-B-077-005
- human hepatitis B virus;
- genus Phyllanthus;
Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multiﬂorus Willd., P. tenellus Roxb. and P. virgatus Forst. f.. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 µm, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5). Copyright © 2003 John Wiley & Sons, Ltd.