Antiplasmodial constituents of Cajanus cajan

Authors

  • George Duker-Eshun,

    1. Chemistry Department, University of Ghana, Legon, Accra, Ghana
    2. Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
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  • Jerzy W. Jaroszewski,

    1. Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
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  • William A. Asomaning,

    1. Chemistry Department, University of Ghana, Legon, Accra, Ghana
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  • Francis Oppong-Boachie,

    1. Centre for Scientific Research into Plant Medicine, Mampong-Akwapim, Ghana
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  • S. Brøgger Christensen

    Corresponding author
    1. Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
    • Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Univer-sitetsparken 2, DK-2100 Copenhagen, Denmark.
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Abstract

Bioactivity-guided fractionation of extracts of roots and leaves of Cajanus cajan afforded 8 compounds: betulinic acid, biochanin A, cajanol, genistein and 2′-hydroxygenistein, longistylin A and C, and pinostrobin. The two stilbenes, longistylin A and C, and betulinic acid showed a moderately high in vitro activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7. Copyright © 2004 John Wiley & Sons, Ltd.

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