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Short Communication
Antifungal activity of steroidal glycosides from Yucca gloriosa L.
Article first published online: 25 APR 2005
DOI: 10.1002/ptr.1644
Copyright © 2005 John Wiley & Sons, Ltd.
1099-1573/asset/cover.gif?v=1&s=6a64569c4c1b0de9f4868274faed96fd9265b457 "Phytotherapy Research")
Additional Information
How to Cite
Favel, A., Kemertelidze, E., Benidze, M., Fallague, K. and Regli, P. (2005), Antifungal activity of steroidal glycosides from Yucca gloriosa L.Phytotherapy Research, 19: 158–161. doi: 10.1002/ptr.1644
Publication History
- Issue published online: 25 APR 2005
- Article first published online: 25 APR 2005
- Manuscript Accepted: 14 DEC 2004
- Manuscript Received: 27 JUL 2004
- Abstract
- References
- Cited By
Keywords:
- Yucca gloriosa;
- steroidal glycoside;
- antifungal activity
Abstract
The antifungal activity of a crude steroidal glycoside extract from Yucca gloriosa flowers, named alexin, was investigated in vitro against a panel of human pathogenic fungi, yeasts as well as dermatophytes and filamentous species. The minimal inhibitory concentration (MIC) was determined by an agar dilution method. Alexin had a broad spectrum of antifungal activity, found to reside entirely in the spirostanoid fraction. The major tigogenyl glycosides, yuccaloeside B and yuccaloeside C, exhibited MICs between 0.39 and 6.25 µg[sol ]mL for all the tested yeast strains except for two (C. lusitaniae and C. kefyr). They were also active against several clinical Candida isolates known to be resistant to the usual antifungal agents. The MICs for the dermatophytes were between 0.78 and 12.5 µg[sol ]mL. The most sensitive filamentous species was A. fumigatus (MIC = 1.56 µg[sol ]mL). For most of the strains, the MICs of both glycosides were similar to those of the reference antifungal agent. Copyright © 2005 John Wiley & Sons, Ltd.