Evaluation of anxiolytic activity of spray dried powders of two South Brazilian Passiflora species
Article first published online: 18 APR 2006
Copyright © 2006 John Wiley & Sons, Ltd.
Volume 20, Issue 5, pages 348–351, May 2006
How to Cite
Reginatto, F. H., De-Paris, F., Petry, R. D., Quevedo, J., Ortega, G. G., Gosmann, G. and Schenkel, E. P. (2006), Evaluation of anxiolytic activity of spray dried powders of two South Brazilian Passiflora species. Phytother. Res., 20: 348–351. doi: 10.1002/ptr.1853
- Issue published online: 18 APR 2006
- Article first published online: 18 APR 2006
- Manuscript Accepted: 23 NOV 2005
- Manuscript Received: 1 NOV 2004
- spray-dried powders;
- anxiolytic activity;
- plus-maze test;
The Passiflora extracts have been used in folk medicine because of its reputed sedative and anxiolytic properties. The present study aimed to compare the potential anxiolytic activity of two Passiflora spray-dried powders obtained from P. alata and P. edulis, known in Brazil as ‘maracujá’. Male adult Swiss rats were treated with 200, 400 and 800 mg/kg of spray-dried powders p.o. and anxiolytic activity was evaluated using the elevated plus-maze test. The spray-dried powders showed anxiolytic activity in doses of 400 and 800 mg/kg. Our results support the potential anxiolytic effect of Passiflora spray-dried powders (P. alata and P. edulis). Copyright © 2006 John Wiley & Sons, Ltd.