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Review Article

The pharmacological effects of Salvia species on the central nervous system

  1. Mohsen Imanshahidi1,
  2. Hossein Hosseinzadeh2,*

Article first published online: 18 APR 2006

DOI: 10.1002/ptr.1898

Issue

Phytotherapy Research

Phytotherapy Research

Volume 20, Issue 6, pages 427–437, June 2006

Additional Information

How to Cite

Imanshahidi, M. and Hosseinzadeh, H. (2006), The pharmacological effects of Salvia species on the central nervous system. Phytother. Res., 20: 427–437. doi: 10.1002/ptr.1898

Author Information

  1. 1

    Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran

  2. 2

    Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775-1365, Mashhad, IR Iran

*Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775-1365, Mashhad, IR Iran.

Publication History

  1. Issue published online: 17 MAY 2006
  2. Article first published online: 18 APR 2006
  3. Manuscript Accepted: 2 FEB 2006
  4. Manuscript Received: 16 AUG 2005

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Keywords:

  • Salvia;
  • CNS;
  • sedative and hypnotic;
  • hallucinogen;
  • analgesic;
  • memory enhancing;
  • anticonvulsant;
  • neuroprotective

Abstract

Salvia is an important genus consisting of about 900 species in the family Lamiaceae. Some species of Salvia have been cultivated world wide for use in folk medicine and for culinary purposes. The dried root of Salvia miltiorrhiza, for example, has been used extensively for the treatment of coronary and cerebrovascular disease, sleep disorders, hepatitis, hepatocirrhosis, chronic renal failure, dysmenorrhea, amenorrhea, carbuncles and ulcers. S. officinalis, S. leriifolia, S. haematodes, S. triloba and S. divinorum are other species with important pharmacological effects. In this review, the pharmacological effects of Salvia species on the central nervous system will be reviewed. These include sedative and hypnotic, hallucinogenic, skeletal muscle relaxant, analgesic, memory enhancing, anticonvulsant, neuroprotective and antiparkinsonian activity, as well as the inhibition of ethanol and morphine withdrawal syndrome. Copyright © 2006 John Wiley & Sons, Ltd.

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