The effect of modified citrus pectin on urinary excretion of toxic elements
Version of Record online: 11 JUL 2006
Copyright © 2006 John Wiley & Sons, Ltd.
Volume 20, Issue 10, pages 859–864, October 2006
How to Cite
Eliaz, I., Hotchkiss, A. T., Fishman, M. L. and Rode, D. (2006), The effect of modified citrus pectin on urinary excretion of toxic elements. Phytother. Res., 20: 859–864. doi: 10.1002/ptr.1953
- Issue online: 21 SEP 2006
- Version of Record online: 11 JUL 2006
- Manuscript Accepted: 11 MAY 2006
- Manuscript Revised: 24 APR 2006
- Manuscript Received: 15 MAR 2006
- NIH NCCAM (National Institutes of Health National Center for Complementary and Alternative Medicine). Grant Number: F31-AT00656-01
- modified citrus pectin;
- heavy metals;
This study was undertaken to evaluate the effect of modified citrus pectin (MCP) on the urinary excretion of toxic elements in healthy individuals. MCP is a reduced molecular weight pectin (weight-average molar mass = 15400) that is mostly linear homogalacturonan with a 3.8% degree of esterification and approximately 10% rhamnogalacturonan II based on the presence of 2-keto-3-deoxy-octonic acid. Subjects ingested 15 g of MCP (PectaSol®, EcoNugenics® Inc., Santa Rosa, California 95407) each day for 5 days and 20 g on day 6. Twenty-four hour urine samples were collected on day 1 and day 6 for comparison with baseline. The urine samples were analysed for toxic and essential elements. In the first 24 h of MCP administration the urinary excretion of arsenic increased significantly (130%, p < 0.05). On day 6, urinary excretion was increased significantly for cadmium (150%, p < 0.05). In addition, lead showed a dramatic increase in excretion (560%, p < 0.08). This pilot trial provides the first evidence that oral administration of MCP increases significantly the urinary excretion of toxic metals in subjects with a ‘normal’ body load of metals. It is suggested that systemic chelation of toxic metals by MCP may in part be attributable to the presence of rhamnogalacturonan II, which has been shown previously to chelate metals. Copyright © 2006 John Wiley & Sons, Ltd.