Antiplasmodial activity of Setaria megaphylla
Article first published online: 18 JAN 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Volume 21, Issue 4, pages 366–368, April 2007
How to Cite
Okokon, J. E., Ubulom, P. M. E. and Udokpoh, A. E. (2007), Antiplasmodial activity of Setaria megaphylla. Phytother. Res., 21: 366–368. doi: 10.1002/ptr.2059
- Issue published online: 22 MAR 2007
- Article first published online: 18 JAN 2007
- Manuscript Revised: 25 OCT 2006
- Manuscript Accepted: 25 OCT 2006
- Manuscript Received: 18 SEP 2006
- Setaria megaphylla;
- Plasmodium berghei berghei
The antimalarial activity of an ethanol leaf extract of Setaria megaphylla was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections. Setaria megaphylla (100–300 mg/kg/day) exhibited a significant (p < 0.05) blood schizonticidal activity in 4-day early infection and in established infection with a significant (p < 0.05) mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. The leaf extract possesses a promising antiplasmodial activity in vivo which can be exploited in malaria therapy. Copyright © 2007 John Wiley & Sons, Ltd.