Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis
Article first published online: 18 JAN 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Volume 21, Issue 4, pages 386–390, April 2007
How to Cite
Bayet, C., Fazio, C., Darbour, N., Berger, O., Raad, I., Chaboud, A., Dumontet, C. and Guilet, D. (2007), Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis. Phytother. Res., 21: 386–390. doi: 10.1002/ptr.2081
- Issue published online: 22 MAR 2007
- Article first published online: 18 JAN 2007
- Manuscript Accepted: 8 NOV 2006
- Manuscript Received: 18 OCT 2006
- Citrus sinensis;
- P-glycoprotein inhibitors
Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2-methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2-methoxycitpressine I and acrimarine E inhibited P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells over-expressing P-glycoprotein. Copyright © 2007 John Wiley & Sons, Ltd.