Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line In Vitro
Version of Record online: 20 APR 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Volume 21, Issue 8, pages 757–761, August 2007
How to Cite
Uddin, S. J., Nahar, L., Shilpi, J. A., Shoeb, M., Borkowski, T., Gibbons, S., Middleton, M., Byres, M. and Sarker, S. D. (2007), Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line In Vitro. Phytother. Res., 21: 757–761. doi: 10.1002/ptr.2159
- Issue online: 17 JUL 2007
- Version of Record online: 20 APR 2007
- Manuscript Accepted: 5 MAR 2007
- Manuscript Received: 3 APR 2006
- Xylocarpus granatum;
- colon cancer;
- cytotoxic activity
Xylocarpus granatum J. König (Meliaceae), commonly known as ‘dhundul’, is a Bangladeshi mangrove tree, and well distributed in a number of other countries of south-east Asia, Australia and east Africa. Traditionally, X. granatum has been used as an astringent and febrifuge, and also for the treatment of fever, malaria, thrush, cholera, dysentery and diarrhoea in many countries including Bangladesh. Two limonoids, gedunin and 1α-hydroxy-1,2-dihydrogedunin, the latter being new, have been isolated from the bark of Xylocarpus granatum by reversed-phase preparative HPLC, and the structures were confirmed by spectroscopic means. The cytotoxic potential of gedunin has been evaluated by the Promega's CellTiter 96 non-radioactive cell proliferation assay using the CaCo-2 colon cancer cell line (IC50 = 16.83 µm). A summary of the biological activities of gedunin reported to date is also presented. Copyright © 2007 John Wiley & Sons, Ltd.