Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries

Authors

  • Shoukat Parvez,

    Corresponding author
    1. National Institute for Biotechnology and Genetic Engineering (NIBGE), P.O. 577, Faisalabad, Pakistan
    • National Institute for Biotechnology and Genetic Engineering (NIBGE), P.O. 577, Faisalabad, Pakistan.
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  • Moonkyu Kang,

    1. Purimed R&D Institute, Kyung Hee University, College of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea
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  • Hwan-Suck Chung,

    1. Purimed R&D Institute, Kyung Hee University, College of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea
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  • Hyunsu Bae

    1. Purimed R&D Institute, Kyung Hee University, College of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea
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Abstract

Tyrosinase is a copper-containing enzyme, which is widely distributed in microorganisms, animals and plants and is a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food products. The inadequacy of current conventional methods to prevent tyrosinase action encourages researchers to seek new potent tyrosinase inhibitors for food and cosmetics.

This article presents a study on the importance of tyrosinase, biochemical characteristics, type of inhibitions, activators from various natural sources with its clinical and industrial importance in recent prospects is discussed in this paper. Copyright © 2007 John Wiley & Sons, Ltd.

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