Antielastase and free radical scavenging activities of compounds from the stems of Cornus kousa
Article first published online: 27 JUL 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Volume 21, Issue 12, pages 1171–1176, December 2007
How to Cite
Sultana, N. and Lee, N. H. (2007), Antielastase and free radical scavenging activities of compounds from the stems of Cornus kousa. Phytother. Res., 21: 1171–1176. doi: 10.1002/ptr.2230
- Issue published online: 29 NOV 2007
- Article first published online: 27 JUL 2007
- Manuscript Accepted: 3 MAY 2007
- Manuscript Received: 25 MAR 2007
- Korean Science and Engineering Foundation (KOSEF)
- Ministry of Commerce, Industry and Energy. Grant Number: 2006-10027299
- Cornus kousa;
Bioassay-guided investigation of the stems of Cornus kousa led to the isolation of 12 compounds such as four triterpenoids: betulinic acid (1), maslinic acid (2), arjunolic acid (3), 3-isoarjunolic acid (4), four flavanoids; catechin (5), epi-catechin (6), 2-hydroxynaringenin (7), 2-hydroxynaringenin-7-O-β-d-glucopyranoside (8), two ellagic acid derivatives; 3,4,3′-tri-O-methylellagic acid (9), 3,4-di-O-methylellagic acid (10), a daucosterol (11) and a sucrose derivative; (3′-O-p-coumaroyl)-β-d-fructofuranosy-(2?1)-(6-O-p-coumaroyl)-α-d-glucopyranoside (12). Their structures were elucidated on the basis of spectroscopic studies as well as by comparison with available data in the literature. The free radical scavenging activity and elastase inhibition activity were investigated for the development of antiaging ingredients as a raw material for use in cosmetics. Among these compounds, compounds 1, 2 and 8 showed significant elastase inhibition activity and IC50 was 10.81 µg/mL, 21.21 µg/mL and 44.63 µg/mL, respectively, on porcine pancreatic elastase, whereas compounds 5, 6, 7 and 8 showed significant free radical scavenging activity and SC50 was 8.37 µg/mL, 9.31 µg/mL, 9.23 µg/mL and 17.45 µg/mL, respectively. Copyright © 2007 John Wiley & Sons, Ltd.