Protective effects of American ginseng (Panax quinquefolium) against mitomycin C induced micronuclei in mice
Article first published online: 27 JUL 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Volume 21, Issue 12, pages 1221–1227, December 2007
How to Cite
Pawar, A. A., Tripathi, D. N., Ramarao, P. and Jena, G. (2007), Protective effects of American ginseng (Panax quinquefolium) against mitomycin C induced micronuclei in mice. Phytother. Res., 21: 1221–1227. doi: 10.1002/ptr.2245
- Issue published online: 29 NOV 2007
- Article first published online: 27 JUL 2007
- Manuscript Accepted: 14 MAY 2007
- Manuscript Revised: 9 MAY 2007
- Manuscript Received: 6 FEB 2007
- NIPER, Communication No. 404
- mitomycin C;
- micronuclei test;
- American ginseng;
Mitomycin C (MMC) is a highly active anticancer drug commonly used alone and in combination with other chemotherapeutic agents for the treatment of different cancers. Its bioactivated form critically damages the DNA present in both rapidly dividing cancerous cells as well as in normal cells. Genotoxicity in the normal cells makes this drug highly toxic; thereby decreasing its therapeutic index for clinical use. The study investigated the chemoprotective potential of American ginseng root extract against MMC by using the micronuclei test in a mouse test system. Pre-treatment with ginseng at doses 50 mg/kg and 100 mg/kg, p.o. for 3 and 7 days significantly decreased the frequency of micronucleated polychromatic erythrocytes (PCEs). Similar protective effects were also observed during co-treatment with ginseng at similar doses for 3 and 7 days. The present results indicate that American ginseng extract is capable of suppressing the chromosomal aberration induced by MMC in mice. Thus, American ginseng may be a potent chemoprotective agent against the toxicity of the anticancer drug, mitomycin C. Copyright © 2007 John Wiley & Sons, Ltd.