Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds
Article first published online: 29 APR 2008
Copyright © 2008 John Wiley & Sons, Ltd.
Volume 22, Issue 6, pages 709–724, June 2008
How to Cite
Asl, M. N. and Hosseinzadeh, H. (2008), Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds. Phytother. Res., 22: 709–724. doi: 10.1002/ptr.2362
- Issue published online: 29 APR 2008
- Article first published online: 29 APR 2008
- Manuscript Accepted: 10 AUG 2007
- Manuscript Revised: 1 AUG 2007
- Manuscript Received: 20 JUN 2006
- Glycyrrhiza glabra;
- glycyrrhitinic acid;
The roots and rhizomes of licorice (Glycyrrhiza) species have long been used worldwide as a herbal medicine and natural sweetener. Licorice root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, and pulmonary and skin diseases, although clinical and experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective and cardioprotective effects. A large number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoids and chalcones, with glycyrrhizic acid normally being considered to be the main biologically active component. This review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical and adverse effects of licorice and its bioactive components. Copyright © 2008 John Wiley & Sons, Ltd.