Effect of SBD.4A – a defined multicomponent preparation of Angelica sinensis – in periodontal regeneration models
Article first published online: 3 APR 2008
Copyright © 2008 John Wiley & Sons, Ltd.
Volume 22, Issue 7, pages 923–928, July 2008
How to Cite
Zhao, H., Alexeev, A., Sharma, V., Guzman, L. D. T. and Bojanowski, K. (2008), Effect of SBD.4A – a defined multicomponent preparation of Angelica sinensis – in periodontal regeneration models. Phytother. Res., 22: 923–928. doi: 10.1002/ptr.2421
- Issue published online: 20 JUN 2008
- Article first published online: 3 APR 2008
- Manuscript Accepted: 4 OCT 2007
- Manuscript Revised: 27 SEP 2007
- Manuscript Received: 22 JUN 2007
- National Institute of Dental and Craniofacial Research. Grant Number: NIH SBIR Phase I grant 1R43DE015741-01A1
- extracellular matrix;
Periodontitis is a major cause of tooth motility and loss, resulting in destruction of the supporting structures of the tooth, including periodontal ligaments and alveolar bone. Periodontal surgery can slow the progression of the disease, but is costly, invasive, limited by contraindications and technique-sensitive. Recently, non-invasive pharmacological treatments using proteinaceous biologicals have become available. Here, for the first time, the bone-regenerative capabilities of a non-proteinaceous biological – SBD.4A – a novel, stable multicomponent growth factor isolated from a medicinal plant Angelica sinensis are reported. SBD.4A was tested in osteoblast proliferation and differentiation systems, as well as in a fibroblast-secreted hyaluronic acid assay. Furthermore, SBD.4A was formulated in a slow release matrix and tested in the rat calvarial defect model. Apart from the previously reported strong stimulation of angiogenesis, fibroblast growth and collagen synthesis – the activities needed for periodontal regeneration – SBD.4A enhanced the deposition of hyaluronic acid and proliferation of osteoblasts in vitro, as well as bone regeneration in the rat calvarial defect model. Together, these results indicate the beneficial effect of SBD.4 on periodontal ligament and bone regeneration making the case for further development of this botanical growth factor. Copyright © 2008 John Wiley & Sons, Ltd.