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Review Article

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders

  1. Caterina Scuderi1,
  2. Daniele De Filippis2,†,
  3. Teresa Iuvone2,†,
  4. Angelo Blasio1,
  5. Antonio Steardo1,
  6. Giuseppe Esposito1,*

Article first published online: 9 OCT 2008

DOI: 10.1002/ptr.2625

Issue

Phytotherapy Research

Phytotherapy Research

Volume 23, Issue 5, pages 597–602, May 2009

Additional Information

How to Cite

Scuderi, C., Filippis, D. D., Iuvone, T., Blasio, A., Steardo, A. and Esposito, G. (2009), Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. Phytother. Res., 23: 597–602. doi: 10.1002/ptr.2625

Author Information

  1. 1

    Department of Physiology and Pharmacology ‘V. Erspamer’, Sapienza University of Rome, Italy

  2. 2

    Department of Experimental Pharmacology, University of Naples ‘Federico II’, Italy

  1. †

    Endocannabinoid Research Group.

*Department of Physiology and Pharmacology, ‘V. Erspamer’, Sapienza University of Rome, P. le A. Moro, 5-00185 Rome, Italy.

  1. †

    Endocannabinoid Research Group.

Publication History

  1. Issue published online: 23 APR 2009
  2. Article first published online: 9 OCT 2008
  3. Manuscript Accepted: 29 MAY 2008
  4. Manuscript Received: 23 MAY 2008

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Keywords:

  • cannabidiol;
  • Cannabis sativa;
  • CNS disorder;
  • phytocannabinoid

Abstract

Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use.

The present review reports the pharmacological profile of CBD and summarizes results from preclinical and clinical studies utilizing CBD, alone or in combination with other phytocannabinoids, for the treatment of a number of CNS disorders. Copyright © 2008 John Wiley & Sons, Ltd.

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