The basis for the antihyperglycemic activity of Indigofera arrecta in the rat
Version of Record online: 5 JUN 2009
Copyright © 1993 John Wiley & Sons, Ltd.
Volume 7, Issue 1, pages 1–4, January/February 1993
How to Cite
Nyarko, A. K., Sittie, A. A. and Addy, M. E. (1993), The basis for the antihyperglycemic activity of Indigofera arrecta in the rat. Phytother. Res., 7: 1–4. doi: 10.1002/ptr.2650070102
- Issue online: 5 JUN 2009
- Version of Record online: 5 JUN 2009
- Manuscript Accepted: 20 JAN 1992
- Indigofera arrecta;
The basis for the antihyperglycaemic property of Indigofera arrecta, a plant used for the treatment of diabetes, was evaluated using normoglycemic and streptozotocin-induced diabetic rats. The rats were given different doses of the freeze-dried extract of the plant material orally and intraperitoneally. The extract decreased the plasma glucose levels of fasting normoglycemic rats, but did not prevent the rise in plasma glucose after an oral glucose load in these rats. The extract increased plasma insulin levels. In the diabetic rats, the rise in blood glucose after an oral glucose load was not affected when the extract was administered 17 days after induction of diabetes. When administered 7 days after induction of diabetes, the rise in blood glucose was decreased, and was stabilized after 30 min. The results indicate that I. arrecta is insulinotropic, requiring functional beta cells to express its effect.