Article

Microbiological properties of protoanemonin isolated from Ranunculus bulbosus

  1. N. Didry1,*,
  2. L. Dubreuil2,
  3. M. Pinkas1

Article first published online: 18 JAN 2006

DOI: 10.1002/ptr.2650070107

Issue

Phytotherapy Research

Phytotherapy Research

Volume 7, Issue 1, pages 21–24, January/February 1993

Additional Information

How to Cite

Didry, N., Dubreuil, L. and Pinkas, M. (1993), Microbiological properties of protoanemonin isolated from Ranunculus bulbosus. Phytother. Res., 7: 21–24. doi: 10.1002/ptr.2650070107

Author Information

  1. 1

    Laboratoires de Pharmacognosie, Faculté de Pharmacie, 3 rue du Professeur Laguesse, Boite Postale 83, 59006 Lille Cédex, France

  2. 2

    Bactériologie, Faculté de Pharmacie, 3 rue du Professeur Laguesse, Boite Postale 83, 59006 Lille Cédex, France

*Laboratoires de Pharmacognosie, Faculté de Pharmacie, 3 rue du Professeur Laguesse, Boite Postale 83, 59006 Lille Cédex, France

Publication History

  1. Issue published online: 18 JAN 2006
  2. Article first published online: 18 JAN 2006
  3. Manuscript Accepted: 23 MAR 1992

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Keywords:

  • protoanemonin;
  • antimicrobials;
  • antibiotics;
  • combinations

Abstract

The antimicrobial properties of protoanemonin isolated from the aerial parts of Ranunculus bulbosus were investigated. By its marked inhibitory effects and its broad spectrum of activity against aerobes and anaerobes including multiresistant pathogenic strains, protoanemonin could be considered as a promising antimicrobial natural compound. Combinations of protoanemonin and antibiotics were also investigated. Twenty two antibiotic-protoanemonin combinations against aerobic bacteria were studied: 20 combinations were partially synergistic (0.5<FIC⩽0.75) and in one case a total synergism (FIC⩽0.5) was observed. This striking result was obtained with the protoanemonin-cefamandole combination against a pathogenic strain of Staphylococcus aureus.

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