Panax ginseng extract improves scopolamine-induced deficits in working memory performance in the T-maze delayed alternation task in rats
Article first published online: 18 JAN 2006
Copyright © 1993 John Wiley & Sons, Ltd.
Volume 7, Issue 1, pages 49–52, January/February 1993
How to Cite
Ni, X.-H., Ohta, H., Watanabe, H. and Matsumoto, K. (1993), Panax ginseng extract improves scopolamine-induced deficits in working memory performance in the T-maze delayed alternation task in rats. Phytother. Res., 7: 49–52. doi: 10.1002/ptr.2650070112
- Issue published online: 18 JAN 2006
- Article first published online: 18 JAN 2006
- Manuscript Accepted: 24 JAN 1992
- Panax ginseng;
- working memory;
- delayed alternation task;
The effects of Panax ginseng water extract on spatial working memory disruption induced by scopolamine were examined using a T-maze delayed alternation task in rats. Scopolamine (0.025–0.1 mg/kg, i.p.) dose-dependently impaired the maze performance, and physostigmine (0.4 mg/kg) significantly reversed the scopolamine (0.1 mg/kg)-induced performance deficits. Ginseng extract (0.5–4.0 g dried root/kg) orally administered 60 min before testing dose-dependently improved the maze performance disrupted by scopolamine (0.1 mg/kg). Ginseng extract given for 7 days in drinking water (2.0 and 4.0 g/kg/day) also exhibited dose-dependent reversal of the scopolamine-induced performance deficits. These data indicate the beneficial effects of ginseng extract on spatial working memory in rats.