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Keywords:

  • crude drugs;
  • Agkistrodon Japonicae;
  • Gecko;
  • Phocae Testis et Penis;
  • Muschus;
  • Bezoar Bovis;
  • protection from stress symptoms in mice

Abstract

Crude drugs derived from the animal sources, Agkistrodon Japonicae (Hampi), Gecko (Goukai), Phocae Testis et Penis (Kaikujin), Muschus (musk) and Bezoar Bovis (bezoar) were studied to determine their effects on sexual and learning behaviour in mice subjected to chronic “hanging stress”. Drugs were given orally once a day for 14 days, sexual (licking, mounting and intromission) and learning (memory retrieval and memory extinction) behaviours were observed. All drugs protected mice against a stress-induced decrease of licking and intromission behaviour, and all drugs, except Goukai, also protected against a decrease in mounting behaviour due to stress. Kaikujin protected mice against the stress-induced increase of acceleration of memory loss and failure of memory retrieval. Hampi, Goukai and bezoar protected mice against stress-induced increase of failure to retrieve memory. Musk protected mice against the stress-induced increase of acceleration of memory loss. These results suggest that these drugs have protective effects against chronically exhausted states.