Effects of crude drugs derived from animal sources on sexual and learning behaviour in chronically stressed mice
Article first published online: 18 JAN 2006
Copyright © 1993 John Wiley & Sons, Ltd.
Volume 7, Issue 1, pages 57–63, January/February 1993
How to Cite
Morishita, S.-I., Shoji, M., Oguni, Y., Hirai, Y., Sugimoto, C. and Ito, C. (1993), Effects of crude drugs derived from animal sources on sexual and learning behaviour in chronically stressed mice. Phytother. Res., 7: 57–63. doi: 10.1002/ptr.2650070114
- Issue published online: 18 JAN 2006
- Article first published online: 18 JAN 2006
- Manuscript Revised: 25 MAR 1992
- crude drugs;
- Agkistrodon Japonicae;
- Phocae Testis et Penis;
- Bezoar Bovis;
- protection from stress symptoms in mice
Crude drugs derived from the animal sources, Agkistrodon Japonicae (Hampi), Gecko (Goukai), Phocae Testis et Penis (Kaikujin), Muschus (musk) and Bezoar Bovis (bezoar) were studied to determine their effects on sexual and learning behaviour in mice subjected to chronic “hanging stress”. Drugs were given orally once a day for 14 days, sexual (licking, mounting and intromission) and learning (memory retrieval and memory extinction) behaviours were observed. All drugs protected mice against a stress-induced decrease of licking and intromission behaviour, and all drugs, except Goukai, also protected against a decrease in mounting behaviour due to stress. Kaikujin protected mice against the stress-induced increase of acceleration of memory loss and failure of memory retrieval. Hampi, Goukai and bezoar protected mice against stress-induced increase of failure to retrieve memory. Musk protected mice against the stress-induced increase of acceleration of memory loss. These results suggest that these drugs have protective effects against chronically exhausted states.