Hepatitis B surface antigen (HBsAg) inactivation and angiotensin-converting enzyme (ACE) inhibition in vitro by Combretum glutinosum perr. (Combretaceae) extract

Authors

  • J. L. Pousset,

    Corresponding author
    1. Laboratoire de Pharmacognosie, Faculté de Médecine et de Pharmacie, 34, Rue du Jardin des Plantes, B.P. 199, 86005 Poitiers Cedex, France
    • Laboratoire de Pharmacognosie, Faculté de Médecine et de Pharmacie, 34, Rue du Jardin des Plantes, B.P. 199, 86005 Poitiers Cedex, France
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  • J. P. Rey,

    1. Laboratoire de Pharmacognosie, Faculté de Médecine et de Pharmacie, 34, Rue du Jardin des Plantes, B.P. 199, 86005 Poitiers Cedex, France
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  • J. Levesque,

    1. Laboratoire de Pharmacognosie, Faculté de Médecine et de Pharmacie, 34, Rue du Jardin des Plantes, B.P. 199, 86005 Poitiers Cedex, France
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  • P. Coursaget,

    1. Institut de Virologie, Faculté de Médecine et de Pharmacie, 2 bis, Boulevard Tonnelé, 37000 Tours, France
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  • F. X. Galen

    1. Laboratoire de Physiologie-Pharmacie, Faculté de Médecine et de Pharmacie, 2, Rue du Docteur Marchand, 87025 Limoges Cedex, France
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Abstract

Among the aqueous extracts of ten African medicinal plants traditionally used for the treatment of hepatic disease and which can inhibit hepatitis B virus antigen (HBsAg) in vitro, extracts from the leaf decoction of Combretum glutinosum proved to be the most active (100–500 ng/mL−1). With solvents of increasing polarity, a precipitate was isolated from the methanolic phase of this extract which contains gallic tannins and these compounds may be responsible for the effect on angiotensin-converting enzyme (ACE).

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