We report that spice, vegetable and fruit extracts inhibit 12–O-tetradecanoylphorbol–13-acetate (TPA)-induced ear oedema in mice. About 100 methanol extracts obtained from spices, vegetables and fruits were assayed and their inhibition ratios calculated. In general, the spice extracts were more effective inhibitors than vegetable and fruit extracts. The methanol extracts of hop, stevia, cinnamon, turmeric, mate, mint, New Zealand spinach, watercress, tomato and seedling of radish markedly inhibited the inflammatory activity induced by TPA in mice. Two active compounds, humulone and lupeol 3-palmitate were separated from hop and stevia, respectively.