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Article

Cardiovascular effects of the aqueous extract of Moringa pterygosperma

  1. Dnyanesh Arun Limaye1,
  2. Anil Yashvant Nimbkar2,
  3. Rajeev Jain3,
  4. Mansoor Ahmad4,*

Article first published online: 20 JAN 2006

DOI: 10.1002/ptr.2650090109

Issue

Phytotherapy Research

Phytotherapy Research

Volume 9, Issue 1, pages 37–40, February 1995

Additional Information

How to Cite

Limaye, D. A., Nimbkar, A. Y., Jain, R. and Ahmad, M. (1995), Cardiovascular effects of the aqueous extract of Moringa pterygosperma. Phytotherapy Research, 9: 37–40. doi: 10.1002/ptr.2650090109

Author Information

  1. 1

    Department of Pharmacology and Toxicology, College of Pharmacy, The University of Rhode Island, Kingston, RI 02881, USA

  2. 2

    Department of Pharmacology and Toxicology, Principal K. M. Kundnani College of Pharmacy, University of Bombay, Bombay 400018, India

  3. 3

    Department of Pharmacognosy and Environmental Health Sciences, College of Pharmacy, The University of Rhode Island, Kingston, RI 02881, USA

  4. 4

    Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan

*Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan

Publication History

  1. Issue published online: 20 JAN 2006
  2. Article first published online: 20 JAN 2006
  3. Manuscript Accepted: 10 DEC 1993

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Keywords:

  • Moringa pterygosperma;
  • Moringaceae;
  • cardiotonic;
  • blood pressure;
  • hypotension

Abstract

The aqueous extract of stem bark of Moriga pterygosperma (Family Moraingaceae) was investigated for its effect on various pharmacological parameters. In cardiovascular profile at lower concentrations (1–10 ng) it produced a dose dependent positive inotropic effect (n = 3, 1.29 ± 0.021 for 10 ng) and at higher concentrations (0.1–1 μg) a dose dependent negative inotropic effect (n = 3, 0.53 ± 0.033 for 1 μg) on the isolated frog heart. It also produced a dose dependent hypotensive effect on dog blood pressure (n = 3, 82 ± 0.98 for 20 mg/kg). It failed to elicit any effect on isolated guinea-pig ileum, rat stomach fundus or frog rectus abdominis muscle.

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