Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part II
Article first published online: 23 JAN 2009
Copyright © 2009 John Wiley & Sons, Ltd.
Volume 23, Issue 8, pages 1109–1115, August 2009
How to Cite
Csupor-Löffler, B., Hajdú, Z., Réthy, B., Zupkó, I., Máthé, I., Rédei, T., Falkay, G. and Hohmann, J. (2009), Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part II. Phytother. Res., 23: 1109–1115. doi: 10.1002/ptr.2755
- Issue published online: 27 JUL 2009
- Article first published online: 23 JAN 2009
- Manuscript Accepted: 7 NOV 2008
- Manuscript Revised: 3 NOV 2008
- Manuscript Received: 25 JUN 2008
- Hungarian Scientific Research Fund. Grant Number: OTKA K72771
- antiproliferative activity;
- cytotoxic activity;
The antiproliferative activities of aqueous and organic extracts prepared from 26 Hungarian species of the tribes Cynereae and Lactuceae (Asteraceae) were tested in vitro against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells by using the MTT assay. Of the tested 200 extracts of different plant parts obtained with n-hexane, chloroform, 50% methanol and water, 16 extracts displayed noteworthy cell growth inhibitory activity (>50% inhibition at a concentration of 10 µg/mL). The IC50 values of these extracts were determined, and their direct cytotoxic effects were measured. High differences between the antiproliferative and cytotoxic activities, demonstrating a real cell proliferation inhibitory activity rather than direct killing effects, were found for some Centaurea, Cirsium, Cichorium, Lactuca, Onopordum and Scorsonera extracts. Copyright © 2009 John Wiley & Sons, Ltd.