Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds

Authors

  • Marjan Nassiri-Asl,

    1. Department of Pharmacology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran
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  • Hossein Hosseinzadeh

    Corresponding author
    1. Corresponding author: Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, 1365-91775 Mashhad, IR Iran
    • Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, 1365-91775 Mashhad, IR Iran.
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Abstract

Vitis vinifera, known as the grapevine, is native to southern Europe and Western Asia. Grape seed and skin contain several active components including flavonoids, polyphenols, anthocyanins, proanthocyanidins, procyanidines, and the stilbene derivative resveratrol. Grape seed extract in particular has been reported to possess a broad spectrum of pharmacological and therapeutic effects such as antioxidative, anti-inflammatory, and antimicrobial activities, as well as having cardioprotective, hepatoprotective, and neuroprotective effects. Thus, the present review attempts to give a short overview on the pharmacological, toxicological, and clinical studies of grape and its active components. Copyright © 2009 John Wiley & Sons, Ltd.

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