Review

Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds

  1. Marjan Nassiri-Asl1,
  2. Hossein Hosseinzadeh2,*

Article first published online: 12 JAN 2009

DOI: 10.1002/ptr.2761

Issue

Phytotherapy Research

Phytotherapy Research

Volume 23, Issue 9, pages 1197–1204, September 2009

Additional Information

How to Cite

Nassiri-Asl, M. and Hosseinzadeh, H. (2009), Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds. Phytother. Res., 23: 1197–1204. doi: 10.1002/ptr.2761

Author Information

  1. 1

    Department of Pharmacology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran

  2. 2

    Corresponding author: Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, 1365-91775 Mashhad, IR Iran

*Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, 1365-91775 Mashhad, IR Iran.

Publication History

  1. Issue published online: 21 AUG 2009
  2. Article first published online: 12 JAN 2009
  3. Manuscript Accepted: 10 NOV 2008
  4. Manuscript Revised: 8 NOV 2008
  5. Manuscript Received: 23 FEB 2008

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Keywords:

  • Vitis vinifera;
  • grape seed;
  • flavonoids;
  • proanthocyanidins;
  • resveratrol;
  • quercetin

Abstract

Vitis vinifera, known as the grapevine, is native to southern Europe and Western Asia. Grape seed and skin contain several active components including flavonoids, polyphenols, anthocyanins, proanthocyanidins, procyanidines, and the stilbene derivative resveratrol. Grape seed extract in particular has been reported to possess a broad spectrum of pharmacological and therapeutic effects such as antioxidative, anti-inflammatory, and antimicrobial activities, as well as having cardioprotective, hepatoprotective, and neuroprotective effects. Thus, the present review attempts to give a short overview on the pharmacological, toxicological, and clinical studies of grape and its active components. Copyright © 2009 John Wiley & Sons, Ltd.

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