Short Communication

Xanthine oxidase inhibiting effects of noni (Morinda citrifolia) fruit juice

  1. Afa Palu*,
  2. Shixin Deng,
  3. Brett West,
  4. Jarakae Jensen

Article first published online: 12 MAY 2009

DOI: 10.1002/ptr.2842

Issue

Phytotherapy Research

Phytotherapy Research

Volume 23, Issue 12, pages 1790–1791, December 2009

Additional Information

How to Cite

Palu, A., Deng, S., West, B. and Jensen, J. (2009), Xanthine oxidase inhibiting effects of noni (Morinda citrifolia) fruit juice. Phytotherapy Research, 23: 1790–1791. doi: 10.1002/ptr.2842

Author Information

  1. Tahitian Noni International Research and Development, 737 East 1180 South American Fork, Utah 84003, USA

*Tahitian Noni International Research and Development, 737 East 1180 South American Fork, Utah 84003, USA.

Publication History

  1. Issue published online: 25 NOV 2009
  2. Article first published online: 12 MAY 2009
  3. Manuscript Accepted: 28 FEB 2009
  4. Manuscript Revised: 23 FEB 2009
  5. Manuscript Received: 19 NOV 2008

Funded by

  • Founders of Morinda, Inc.

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (53K)

Keywords:

  • xanthine oxidase;
  • noni;
  • gout;
  • Morinda citrifolia

Abstract

Morinda citrifolia L. (noni), family Rubiaceae, has been used in Polynesia for over 2000 years for its reputed health benefits, one of which is its therapeutic effects on gout (langa e hokotanga hui). However, its healing mechanism has not been elucidated. This study showed that in an in vitro bioassay that Tahitian Noni® Juice (TNJ) inhibited xanthine oxidase (XO) concentration dependently. Concentrations of 1, 5 and 10 mg/mL of TNJ inhibited XO by 11%, 113% and 148%, respectively, with an IC50 of 3.8 mg compared with an IC50 of 2.4 µm for allopurinol. Noni fruit juice concentrate (NFJC) also inhibited XO concentration dependently. Concentrations of 1 and 5 mg/mL NFJC inhibited XO in vitro by 184% and 159%, respectively. A 0.1 mg/mL methanol extract (NFJME) from the fractionation of noni fruit puree inhibited XO by 64%. It was elucidated that the noni fruit juice inhibitory effect on XO enzymes is the mechanism by which noni ameliorates gout and gout-like diseases. Further, the results also support the traditional usage of noni in the treatment of gout. Copyright © 2009 John Wiley & Sons, Ltd.

Get PDF (53K)