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Short Communication
Influence of palm oil on doxorubicin induced cytotoxicity in normal and tumor cell cultures
Article first published online: 15 MAY 2009
DOI: 10.1002/ptr.2878
Copyright © 2009 John Wiley & Sons, Ltd.
1099-1573/asset/cover.gif?v=1&s=6a64569c4c1b0de9f4868274faed96fd9265b457 "Phytotherapy Research")
Additional Information
How to Cite
Dan Postescu, I., Virag, P., Achim, M. and Fischer-Fodor, E. (2010), Influence of palm oil on doxorubicin induced cytotoxicity in normal and tumor cell cultures. Phytotherapy Research, 24: 154–156. doi: 10.1002/ptr.2878
Publication History
- Issue published online: 24 DEC 2009
- Article first published online: 15 MAY 2009
- Manuscript Accepted: 25 MAR 2009
- Manuscript Revised: 10 FEB 2009
- Manuscript Received: 6 AUG 2008
- Abstract
- References
- Cited By
Keywords:
- palm oil;
- tocotrienols;
- doxorubicin;
- cytotoxicity
Abstract
The vitamin E of palm oil, unlike most other vegetal fats, consists largely of tocotrienols (TT), products previously reported as having antioxidant and tumor-inhibitory properties. A tocotrienols containing palm oil, in the form of liposomes entrapping dosages of 0.5–0.05 µgTT/mL, was studied in combined treatments with doxorubicin (30 min before drug administration). The IC50 values of doxorubicin, at 24 h, showed that its cytotoxic effects were decreased by palm oil, in a dose effect relationship (p < 0.01, ANOVA), in both normal (Hfl-1, Huvec) and tumor (HepG2, Mls) cells. These results demonstrated an unselective protective activity of tocotrienols, in vitro, on some normal and tumor cultured cells treated with doxorubicin. Copyright © 2009 John Wiley & Sons, Ltd.