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Antimicrobial and cytotoxic activities of Malaysian endophytes

  1. Kalavathy Ramasamy1,*,
  2. Siong Meng Lim1,
  3. Hamidah Abu Bakar1,
  4. Noorliana Ismail1,
  5. Maria Suhana Ismail1,
  6. Muhamad Fuad Ali1,
  7. Jean-Frédéric Faizal Weber2,
  8. Anthony L. J. Cole3

Article first published online: 26 MAY 2009

DOI: 10.1002/ptr.2891

Issue

Phytotherapy Research

Phytotherapy Research

Volume 24, Issue 5, pages 640–643, May 2010

Additional Information

How to Cite

Ramasamy, K., Lim, S. M., Bakar, H. A., Ismail, N., Ismail, M. S., Ali, M. F., Faizal Weber, J.-F. and Cole, A. L. J. (2010), Antimicrobial and cytotoxic activities of Malaysian endophytes. Phytotherapy Research, 24: 640–643. doi: 10.1002/ptr.2891

Author Information

  1. 1

    Collaborative Drug Discovery Research (CDDR) Group, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 40450, Shah Alam, Selangor Darul Ehsan, Malaysia

  2. 2

    Institute for the Study of Natural Remedies (IKUS), Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 40450, Shah Alam, Selangor Darul Ehsan, Malaysia

  3. 3

    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand

*Collaborative Drug Discovery Research (CDDR) Group, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 40450, Selangor Darul Ehsan, Malaysia.

Publication History

  1. Issue published online: 27 APR 2010
  2. Article first published online: 26 MAY 2009
  3. Manuscript Accepted: 4 APR 2009
  4. Manuscript Revised: 16 MAR 2009
  5. Manuscript Received: 31 MAR 2008

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Keywords:

  • endophytes;
  • anticancer;
  • cytotoxic;
  • antimicrobial

Abstract

Endophytes, which are receiving increasing attention, have been found to be potential sources of bioactive metabolites following the discovery of paclitaxel producing endophytic fungi. In the present study, a total of 348 endophytes were isolated from different parts of 24 Malaysian medicinal plants. Three selected endophytes (HAB10R12, HAB11R3 and HAB21F25) were investigated for their antimicrobial and cytotoxic activities. For antimicrobial activity, HAB10R12 and HAB11R3 were found to be most active against bacteria and fungi, respectively. Their antimicrobial effects were comparable to, if not better than, a number of current commercial antibacterial and antifungal agents. Both HAB10R12 and HAB21F25 were found to be potential anticancer drug candidates, having potent activity against MCF-7 and HCT116 cell lines and warrant further investigation. Copyright © 2009 John Wiley & Sons, Ltd.

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