In vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu
Article first published online: 14 DEC 2009
Copyright © 2009 John Wiley & Sons, Ltd.
Volume 24, Issue 6, pages 800–809, June 2010
How to Cite
Bradacs, G., Maes, L. and Heilmann, J. (2010), In vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu. Phytother. Res., 24: 800–809. doi: 10.1002/ptr.2981
- Issue published online: 26 MAY 2010
- Article first published online: 14 DEC 2009
- Manuscript Accepted: 5 JUL 2009
- Manuscript Revised: 3 JUL 2009
- Manuscript Received: 24 MAR 2009
- traditional medicine;
Sixty-three extracts obtained from 18 plants traditionally used in the South Pacific archipelago Vanuatu for the treatment of infectious diseases were screened for antimicrobial and antiprotozoal activities. In addition, the extracts were subjected to a detailed analysis on cytotoxic effects toward a panel of human cancer cell lines, designed as a smaller version of the NCI60 screen. Intriguingly, 15 plant extracts exhibited strong cytotoxic effects specific for only one cancer cell line. Extracts of the leaves of Acalypha grandis Benth. significantly affected Plasmodium falciparum without showing obvious effects against the other protozoa tested. The leaves of Gyrocarpus americanus Jacq. displayed significant activity against Trypanosoma b. brucei and the leaves of Tabernaemontana pandacaqui Lam. I as well as the stems of Macropiper latifolium (L.f.) against Trypanosoma cruzi. In contrast none of the extracts showed relevant antibacterial or antifungal activity. Copyright © 2009 John Wiley & Sons, Ltd.