Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells
Article first published online: 1 JUN 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Volume 24, Issue 10, pages 1538–1542, October 2010
How to Cite
Hoi, C. P., Ho, Y. P., Baum, L. and Chow, A. H. L. (2010), Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells. Phytother. Res., 24: 1538–1542. doi: 10.1002/ptr.3178
- Issue published online: 1 JUN 2010
- Article first published online: 1 JUN 2010
- Manuscript Accepted: 4 MAR 2010
- Manuscript Revised: 3 MAR 2010
- Manuscript Received: 11 NOV 2009
- Alzheimer's disease;
Amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which might play a role in Alzheimer's disease. In this regard, the toxic effect of Aβ on a cultured Aβ-sensitive neuronal cell line was used as a primary screening tool for potential anti-Alzheimer's therapeutic agents. The effects of nine pure compounds (vitamin E, α-asarone, salidroside, baicolin, magnolol, gastrodin, bilobalide, honokiol and β-asarone) from selected Chinese herbs on neuronal cell death induced by Aβ in NGF-differentiated PC12 cells were examined. Only two of the studied compounds, honokiol and magnolol, significantly decreased Aβ-induced cell death. Further experiments indicated that their neuroprotective effects are possibly mediated through reduced ROS production as well as suppression of intracellular calcium elevation and inhibition of caspase-3 activity. The results provide for the first time a scientific rationale for the clinical use of honokiol and magnolol in the treatment of Alzheimer's disease. Copyright © 2010 John Wiley & Sons, Ltd.