Research Article

In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: An approach to their mechanisms of action

  1. Ángel L. Álvarez1,
  2. Solomon Habtemariam2,
  3. Malindra Juan-Badaturuge2,
  4. Caroline Jackson3,
  5. Francisco Parra1,*

Article first published online: 20 DEC 2010

DOI: 10.1002/ptr.3382

Issue

Phytotherapy Research

Phytotherapy Research

Volume 25, Issue 2, pages 296–301, February 2011

Additional Information

How to Cite

Álvarez, Á. L., Habtemariam, S., Juan-Badaturuge, M., Jackson, C. and Parra, F. (2011), In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: An approach to their mechanisms of action. Phytother. Res., 25: 296–301. doi: 10.1002/ptr.3382

Author Information

  1. 1

    Instituto Universitario de Biotecnología de Asturias, Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, c/Fernando Bongera s/n, 33006 Oviedo, Spain

  2. 2

    Pharmacognosy Research Laboratories, Medway School of Science, The University of Greenwich, Central Avenue, Chatham-Maritime, Kent ME4 4TB, UK

  3. 3

    Hadlow College, Hadlow, Tonbridge, Kent TN11 0AL, UK

*Instituto Universitario de Biotecnología de Asturias, Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, c/Fernando Bongera s/n, 33006 Oviedo, Spain

Publication History

  1. Issue published online: 31 JAN 2011
  2. Article first published online: 20 DEC 2010
  3. Manuscript Accepted: 15 NOV 2010
  4. Manuscript Revised: 12 NOV 2010
  5. Manuscript Received: 16 JUL 2010

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (274K)

Keywords:

  • Tanacetum vulgare;
  • tansy;
  • antiviral;
  • HSV;
  • ethnomedicine

Abstract

Herpes simplex viruses (HSV-1 and HSV-2) are responsible for long-term latent infections in humans, with periods of recurring viral replication associated to lesions around the lips, eyes, mucous membrane of the oral cavity or the genitals. The lack of an effective vaccine, the moderate to high toxicity of the available synthetic antiherpes compounds and the appearance of resistant viral strains emphasize the need for new inhibitors. Tanacetum vulgare, commonly known as tansy, has been used for treating rheumatic pain, skin eruption and diuretic conditions as well as an anthelmintic, antihypertensive, stimulant, emmenagogue, carminative, antiseptic, antihypertensive, antispasmodic and antioxidant agent. The anti HSV-1 activity of tansy aerial parts, ethyl acetate extract and the isolated compound parthenolide, has been reported recently. In this work, through a comprehensive mechanistic-based antiherpetic activity study, it was revealed that constituents other than parthenolide are responsible for the antiviral activity of tansy. Copyright © 2010 John Wiley & Sons, Ltd.

View Full Article (HTML) Get PDF (274K)