Research Article

Photoprotective Effects of Topical Formulations Containing a Combination of Ginkgo biloba and Green Tea Extracts

  1. Susi Elaine Dal Belo,
  2. Lorena Rigo Gaspar,
  3. Patrícia Maria Berardo Gonçalves Maia Campos*

Article first published online: 25 APR 2011

DOI: 10.1002/ptr.3507

Issue

Phytotherapy Research

Phytotherapy Research

Volume 25, Issue 12, pages 1854–1860, December 2011

Additional Information

How to Cite

Belo, S. E. D., Gaspar, L. R. and Campos, P. M. B. G. M. (2011), Photoprotective Effects of Topical Formulations Containing a Combination of Ginkgo biloba and Green Tea Extracts. Phytotherapy Research, 25: 1854–1860. doi: 10.1002/ptr.3507

Author Information

  1. Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Department of Pharmaceutical Sciences, Ribeirão Preto, Brazil

*Patrícia Maria Berardo Gonçalves Maia Campos, Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Department of Pharmaceutical Sciences, Av. do Café s/n, CEP: 14040–903, Ribeirão Preto, São Paulo, Brazil.
E-mail: pmcampos@usp.br

Publication History

  1. Issue published online: 22 NOV 2011
  2. Article first published online: 25 APR 2011
  3. Manuscript Accepted: 22 MAR 2011
  4. Manuscript Revised: 12 FEB 2011
  5. Manuscript Received: 21 OCT 2010

Funded by

  • Conselho Nacional de Desenvolvimento Científico e Tecnológico. Grant Number: 132693/2004
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Grant Number: 99/07259-0

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Keywords:

  • Ginkgo biloba;
  • green tea;
  • UV radiation;
  • in vivo skin protection;
  • TEWL;
  • topical formulations

The beneficial photoprotective effects of topical formulations containing combined extracts of Ginkgo biloba (GB) and green tea (GT) have not been investigated. The present study aims to assess the photoprotective effects of topical formulations containing GB and GT combined or not by applications on the dorsal skin of hairless mice prior to UVA/B irradiation. After 20 h, skin barrier damage (TEWL), erythema, histological alterations and sunburn cell formation were evaluated. The results showed that only extract supplemented formulations protected the skin against the UV-induced damage. Formulations containing GB provided total protection of the skin barrier function avoiding UV radiation damage such as TEWL and erythema and were more effective than those containing GT. However, it is suggested that formulations containing combined GB and GT may provide substantial photoprotective effects since different aspects of skin damage were influenced by each extract. Copyright © 2011 John Wiley & Sons, Ltd.

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