Antidiabetic Effect of the Total Polyphenolic Acids Fraction from Salvia miltiorrhiza Bunge in Diabetic Rats

Authors

  • Mingqing Huang,

    1. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China
    2. State Key Laboratory of Quality Research in Chinese Medicine, Macau, China
    3. Institute of Chinese Medical Sciences, University of Macau, Macau, China
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    • These authors contributed equally to this work.

  • Youliang Xie,

    1. Institute of Drug Research and Development, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
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    • These authors contributed equally to this work.

  • Lidian Chen,

    1. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China
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  • Kedan Chu,

    1. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China
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  • Shuisheng Wu,

    1. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China
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  • Jinjian Lu,

    1. College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
    2. State Key Laboratory of Quality Research in Chinese Medicine, Macau, China
    3. Institute of Chinese Medical Sciences, University of Macau, Macau, China
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  • Xiuping Chen,

    1. State Key Laboratory of Quality Research in Chinese Medicine, Macau, China
    2. Institute of Chinese Medical Sciences, University of Macau, Macau, China
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  • Yitao Wang,

    1. State Key Laboratory of Quality Research in Chinese Medicine, Macau, China
    2. Institute of Chinese Medical Sciences, University of Macau, Macau, China
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  • Xiaoping Lai

    Corresponding author
    • Institute of Drug Research and Development, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
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Xiaoping Lai, Institute of Drug Research and Development, Guangzhou University of Chinese Medicine, No. 232 Waihuan Road, Guangzhou 510405, China.

E-mail: lxp88@gzhtcm.edu.cn

Abstract

An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting blood glucose (FBG), fasting blood insulin (FINS), total cholesterol (TC), triglyceride (TG) and blood urea nitrogen (BUN), and an obvious increase in insulin sensitivity index (ISI) in diabetic rats induced by a high fat diet and a low dose of streptozocin (STZ). These results suggested that PAF has antidiabetic potential in vivo. Copyright © 2011 John Wiley & Sons, Ltd.

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