Phytochemical, Antioxidant and Anti-α-glucosidase Activity Evaluations of Bergenia cordifolia
Article first published online: 22 NOV 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Volume 26, Issue 6, pages 908–914, June 2012
How to Cite
Roselli, M., Lentini, G. and Habtemariam, S. (2012), Phytochemical, Antioxidant and Anti-α-glucosidase Activity Evaluations of Bergenia cordifolia. Phytother. Res., 26: 908–914. doi: 10.1002/ptr.3655
- Issue published online: 4 JUN 2012
- Article first published online: 22 NOV 2011
- Manuscript Accepted: 5 AUG 2011
- Manuscript Revised: 4 AUG 2011
- Manuscript Received: 6 JUL 2011
- Bergenia cordifolia;
- (+)-catechin gallates;
- 1,2,4,6-tetra-O-galloyl-β- d-glucopyranoside
The antioxidant, anti-α-glucosidase and anticholinesterase activity of the leaves and rhizomatous extract of Bergenia cordifolia were investigated. The rhizomes extract that showed a higher degree of 1,1-diphenyl-2-picrylhydrazyl radical scavenging and anti-α-glucosidase activity than reference compounds (rutin and acarbose respectively) were subjected to phytochemical analysis. The study revealed that previously unknown minor constituents from the plant, (+)-catechin 3-O-gallate, (+)-catechin 3,5-di-O-gallate and 1,2,4,6-tetra-O-galloyl-β- d-glucopyranoside, were the radical scavenging and anti-α-glucosidase principles. These compounds as well as the crude extracts were weak acetylcholienesterase inhibitors, suggesting a higher degree of selectivity against α-glucosidase enzyme. In comparison with the minor constituents, the previously known major constituents of the plant, bergenin and arbutin, were poor radical scavengers and enzyme inhibitors. Copyright © 2011 John Wiley & Sons, Ltd.